Week 4 of the 2022 NFL season features the first London game of the season, a Super Bowl 55 rematch, and a few key divisional matchups. Let’s take a look at NFL Week 4 odds across the top online sportsbooks. If any of these point spreads, moneylines, or totals pique your interest you can get in on the action with thousands of dollars in sports betting bonuses.
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NFL Week 4 Odds
These odds have been posted by DraftKings Sportsbook.
DATE/TIME MATCHUP MONEYLINE POINT SPREAD TOTAL
Thursday, Sept. 29, 7:15 p.m. CT Miami at Cincinnati Miami +100
Miami +1.5 (-110)
Cincinnati -1.5 (-110)
Over 48 (-110)
Under 48 (-110)
Sunday, Oct. 2, 9:30 a.m. CT Minnesota vs. New Orleans Minnesota -115
New Orleans -105
Minnesota -1 (-110)
New Orleans +1 (-110)
Over 44.5 (-110)
Under 44.5 (-110)
Sunday, Oct. 2, Noon CT Jacksonville at Philadelphia Sunday, Oct. 2, Noon CT N.Y. Jets at Pittsburgh Steelers Sunday, Oct. 2, Noon CT Washington at Dallas Sunday, Oct. 2, Noon CT Buffalo at Baltimore Sunday, Oct. 2, Noon CT L.A. Chargers at Houston Sunday, Oct. 2, Noon CT Tennessee at Indianapolis Sunday, Oct. 2, Noon CT Cleveland at Atlanta Sunday, Oct. 2, Noon CT Seattle at Detroit Sunday, Oct. 2, Noon CT Chicago at N.Y. Giants Sunday, Oct. 2, 3:05 p.m. CT Arizona at Carolina Sunday, Oct. 2, 3:25 p.m. CT Denver at Las Vegas Sunday, Oct. 2, 3:25 p.m. CT New England at Green Bay Sunday, Oct. 2, 7:30 p.m. CT Kansas City at Tampa Bay Monday, Oct. 3, 7:15 p.m. CT L.A. Rams at San Francisco
Week 4 Games to Watch
Miami Dolphins at Cincinnati Bengals (-3, 47)
Thursday Night’s Week 4 matchup between the Dolphins and Bengals features two high-powered offenses, and the 47-point game total is currently tied for the fourth-highest of the week. The Dolphins are coming off a huge divisional win against the Buffalo Bills while the Bengals got their offense back on track and their first win with the help of the New York Jets.
It will be interesting to see what (if anything) comes of the NFLPA’s investigation concerning Dolphins’ quarterback Tua Tagovailoa returning to Sunday’s game following a concussion check.
— Tom Pelissero (@TomPelissero) September 25, 2022
New Orleans Saints vs. Minnesota Vikings (-2.5, 44)
Our first of three London games will feature the Vikings and Saints in a game where the spread has been bet down a half-point since opening at -3 in favor of Minnesota.
Both teams are dealing with important offensive injuries, as Vikings running back Dalvin Cook suffered a dislocated shoulder in Week 3, and the Saints lost receivers Michael Thomas (toe), Jarvis Landry (ankle), and Tre’Quan Smith (concussion).
Jacksonville Jaguars at Philadelphia Eagles (-7, 47.5)
Coming off a 38-10 dismantling of the Los Angeles Chargers, the new-look Jaguars will be looking to carry the momentum against one of the hottest teams in the NFL — the Philadelphia Eagles. Jalen Hurts has thrown for 673 yards and 4 scores in his past two games and is currently third in the NFL in passing yards (916).
Buffalo Bills (-3, 53) at Baltimore Ravens
The highest total of the week, two of the five first-round quarterbacks from the 2018 NFL Draft will square off as Josh Allen and the Bills travel to Baltimore to take on Lamar Jackson and the Ravens.
The spread had reached 3.5 before coming back down to 3, and the total was as high as 55 just a few days ago.
Denver Broncos at Las Vegas Raiders (-1.5, 44)
Russell Wilson gets his first AFC West divisional matchup as a Bronco with a trip to Las Vegas. The Raiders will be looking for their first win of the 2022 season following three losses by six points or fewer.
Kansas City Chiefs (-3, 47) at Tampa Bay Buccaneers
The Super Bowl 55 rematch has lost a bit of its luster with Tampa Bay struggling offensively due to an absolute barrage of injuries to start the season. The Bucs have yet to score more than 20 points — a mark the team failed to reach in three games all of last season.
On Sept. 22, this line was -1 in favor of Kansas City with a total of 48.5, with money clearly favoring the Chiefs and the under.
LA Rams at San Francisco 49ers (-1.5, 46)
Week 4 of the NFL concludes with an NFC West battle between the defending Super Bowl champion Rams and the 49ers. The total for this game has dropped a full point from Sunday night to Monday morning while some money has come in on the Rams, dropping the spread from -2 to -1.5.
Contributed by Cody Kutzer